National Centre for the Replacement Refinement and Reduction of Animals in Research

Research council, England

Also known as 3Rs, NC3Rs, Three Rs

United Kingdom

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Open calls 0

Given in 2025 £3.7m

Typical grant £135k Middle half £100k to £182k

New grantees in 2025 0% first grant from this funder

Giving by year

£4.2m 2016 13

£3.9m 2017 20

£3.0m 2018 13

£3.0m 2019 18

£2.7m 2020 13

£5.2m 2021 25

£2.8m 2022 13

£8.0m 2023 33

£3.0m 2024 6

£3.7m 2025 21

0% of 2025 grantees were new to this funder 59% of grantees are funded again within three years

Amount and number of grants we hold records for in each year, which can be less than everything the funder gave. The current year is incomplete.

Where it gives

London 68 grants · typical £205k

Scotland 40 grants · typical £204k

South East 40 grants · typical £179k

North West 30 grants · typical £202k

East Midlands 22 grants · typical £322k

Yorkshire and The Humber 21 grants · typical £337k

South West 20 grants · typical £200k

North East 20 grants · typical £116k

Top local authority areas

Kensington and Chelsea 20 grants · typical £205k

Oxford 17 grants · typical £182k

Westminster 16 grants · typical £229k

City of Edinburgh 16 grants · typical £206k

Nottingham 15 grants · typical £357k

Glasgow City 12 grants · typical £250k

Guildford 8 grants · typical £198k

Cardiff 6 grants · typical £137k

Liverpool 5 grants · typical £76k

Leicester 4 grants · typical £167k

All years we hold. Grants with no recorded place are left out.

Latest grants made

King's college London Using a novel human 3D spheroid model to study mechanisms and therapeutics for vascular calcification £100k 1 Oct 2025

University of surrey Mature human iPSC-derived atrial cardiomyocytes to replace animals in the study of atrial fibrillation £135k 1 Oct 2025

University of southampton Developing patient derived tumour organoids to replace mouse models in understanding and improving anti-tumour T cell responses. £100k 1 Oct 2025

University of Strathclyde Development of 'human stroke-on-a-chip' model to replace rodent stroke models £100k 1 Oct 2025

Newcastle university Using a defined 3D human organoid model to replace the use of animals in the screening and evaluation of treatments for prostate cancer £100k 25 Sep 2025

Newcastle university Validating methods to cryopreserve, store and revive human precision cut tissue slices for disease modelling and drug testing. £100k 15 Sep 2025

University of York Multi-omic analysis of human poor risk acute myeloid leukaemia to replace xenotransplantation assays and expand leukaemic stem cells £135k 12 Sep 2025

Imperial college London Combining machine learning and human skin explant models to harness beneficial skin microbes to treat atopic dermatitis. £100k 1 Sep 2025

University of Glasgow Human sensory neuron and macrophage co-culture; developing a model to test agents capable of disrupting painful neuroimmune signalling £135k 11 Aug 2025

University of Nottingham Integrated training and data sharing to accelerate adoption of 3Rs technology in trypanosome infection research £191k 1 Aug 2025

Data: Contains public sector information licensed under the Open Government Licence v3.0 (UKRI Gateway to Research). (Open Government Licence v3.0); Contains public sector information licensed under the Open Government Licence v3.0 (UKRI Gateway to Research) (Open Government Licence v3.0)